Gene associated with autism also controls growth o

来源:hongwy.com   作者:   发表时间:2020-02-13 03:47:08

"This discovery really broadens the scope of where we think Foxp1 is important," said Bennett Novitch, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA and the senior author of the paper. "And this gives us an expanded way of thinking about how its mutation affects patients."

"Almost all of the attention has been placed on the expression of Foxp1 in neurons that are already formed," said Novitch, a UCLA professor of neurobiology who holds the Ethel Scheibel Chair in Neuroscience.

When mice lacked Foxp1, however, there were fewer apical radial glia at early stages of brain development, as well as fewer of the deep brain cells they normally produce. When levels of Foxp1 were above normal, the researchers observed more apical radial glia and an excess of those deep brain cells that appear early in development. In addition, continued high levels of Foxp1 at later stages of embryonic development led to unusual patterns of apical radial glia production of deep-layer neurons even after the mice were born.

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